Effects of Prosopis farcta Root Extract in the Vascular Reactivity of Isolated Goat Coronary Artery
https://doi.org/10.24017/science.2019.ICHMS.1
Abstract views: 1468 / PDF downloads: 853Abstract
Prosopis species is a medicinal plant, well-known for its beneficial effects in treating various smooth muscles disorders, and its phytochemical analysis revealed the presence of different bioactive compounds in different parts of the plant, most of which show a great role in reducing cardiovascular risks. In the present study, the cardiovascular effect of Prosopis farcta Root Extract (PFRE) was investigated in vitro for possible mechanisms of the extract effect in the vascular reactivity of isolated goat coronary artery (CA) using Organ bath and PowerLab Data Acquisition system. The results of the recording and analyzing of the effect of the PFRE in isolated CA, showed the negative inotropic activity of the extract in CA rings with intact-endothelium, while in CA ring with hyperglycemic-induced endothelium dysfunction the extract tended to vasodilate the CA ring non-significantly, and the extract induced dose-dependent vasodilation in CA rings pre-constricted with high concentration of (30 mM)KCl and showed no effects on contractions induced by (1X10-3-1X10-5) Phenylephrine PE, which is an indicator for its blockade activity on L-type voltage-dependent Ca+2 channel and non-interfering of the extract with the receptor-operated Ca+2 channel. The mechanical recording of the CA ring activities, revealed different potassium (K+) channels including selective calcium-activated potassium channel, ATP-sensitive potassium channel, and different endothelium-derived relaxing factors (EDRF) including nitric oxide and Prostacyclin (PGI2 ) seems to have no role in the relaxation effects of the extract, while the endothelium derived-hyperpolarizing factor (EDHF); epoxy eicosatrienoic acid (EET) showed significant participation in the vasodilation effects of the extract. On the other hand, the extract tended to relax the CA rings through its antagonizing of Ca+2, reducing and inhibiting Ca+2 influx and release from internal stores and interfering with the voltage-operated Ca+2 channels through its alkaloid and flavonoid active compounds which suggested to be the most predicted mechanisms for the maintenance of vasodilating tone and coronary circulation of the PFRE in coronary artery.
Keywords:
Prosopis farcta, vascular reactivity, K channels, Ca 2 channels, endothelium-derived relaxing factors, endothelium derived-hyperpolarizing factor
References
[1] X. Xiong, F. Borrelli, A. de Sá Ferreira, T. Ashfaq, and B. Feng, "Herbal medicines for cardiovascular diseases," Evidence-Based Complementary and Alternative Medicine, vol. 2014, 2014.
https://doi.org/10.1155/2014/809741
[2] C. Liu and Y. Huang, "Chinese herbal medicine on cardiovascular diseases and the mechanisms of action," Frontiers in pharmacology, vol. 7, p. 469, 2016.
https://doi.org/10.3389/fphar.2016.00469
[3] H. S. Siddiqi, M. H. Mehmood, N. U. Rehman, and A. H. Gilani, "Studies on the antihypertensive and antidyslipidemic activities of Viola odorata leaves extract," Lipids in health and disease, vol. 11, p. 6, 2012.
https://doi.org/10.1186/1476-511X-11-6
[4] H. A. Twaij and E. A. Al-Dujaili, "Evaluation of the anti-diabetic and anti-ulcer properties of some Jordanian and Iraqi medicinal plants; a screening study," JMED Research, vol. 2014, 2014.
https://doi.org/10.5171/2014.539605
[5] E. Karimi, A. Aidy, and N. Abbasi, "Quantitative HPLC Analysis of Phenolic Compounds in Prosopis Farcta from two Different Ecological Zones of Iran," Chem Technol Ind J, vol. 12, p. 116, 2017.
[6] A. M. Saad, M. A. Ghareeb, M. S. Abdel-Aziz, H. M. F. Madkour, O. M. Khalaf, A. K. El-Ziaty, et al., "Chemical constituents and biological activities of different solvent extracts of Prosopis farcta growing in Egypt," Journal of Pharmacognosy and Phytotherapy, vol. 9, pp. 67-76, 2017.
https://doi.org/10.5897/JPP2017.0452
[7] A. Al-jeboory and K. F. Dizaye, "Cardiovascular effects of vitexin isolated from Prosopis farcta," Iraqi Journal of Pharmacy, vol. 6, pp. 14-19, 2006.
https://doi.org/10.33899/iphr.2006.50547
[8] M. S. Ali-Shtayeh, R. M. Jamous, J. H. Al-Shafie, W. A. Elgharabah, F. A. Kherfan, K. H. Qarariah, et al., "Traditional knowledge of wild edible plants used in Palestine (Northern West Bank): a comparative study," Journal of Ethnobiology and Ethnomedicine, vol. 4, p. 13, 2008.
https://doi.org/10.1186/1746-4269-4-13
[9] M. Mollashahi, M. Tehranipour, J. Khayyatzade, and B. ZahraJavad Moosavi, "The neuroprotective effects of Prosopis farcta pod aqueous and ethanol extracts on spinal cord ?-motoneurons neuronal density after sciatic nerve injury in rats," Life Sci. J, vol. 10, pp. 293-297, 2013.
[10] A. Moayeri, M. Azimi, E. Karimi, A. Aidy, and N. Abbasi, "Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats," Medical science monitor basic research, vol. 24, p. 151, 2018.
https://doi.org/10.12659/MSMBR.909930
[11] S. Al-Quran, "Taxonomical and pharmacological survey of therapeutic plants in Jordan," J Nat Prod, vol. 1, pp. 10-26, 2008.
[12] A. Ranjbar-Heidari, J. Khaiatzadeh, N. Mahdavi-Shahri, and M. Tehranipoor, "The effect of fruit pod powder and aquatic extract of Prosopis farcta on healing cutaneous wounds in diabetic rat," ???? ??????? ???? ????? ??????, vol. 14, pp. 16-20, 2012.
[13] M. Dashtban, H. Sarir, and A. Omidi, "The effect of Prosopis farcta beans extract on blood biochemical parameters in streptozotocin-induced diabetic male rats," Advanced biomedical research, vol. 5, 2016.
https://doi.org/10.4103/2277-9175.185575
[14] A. L. Lamarque, D. M. Maestri, N. R. Grosso, J. A. Zygadlo, and C. A. Guzmán, "Proximate composition and seed lipid components of some Prosopis (Leguminosae) from Argentina," Journal of the Science of Food and Agriculture, vol. 66, pp. 323-326, 1994.
https://doi.org/10.1002/jsfa.2740660309
[15] B. Huisamen, C. George, S. Genade, and D. Dietrich, "Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes," Cardiovascular journal of Africa, vol. 24, p. 10, 2013.
https://doi.org/10.5830/CVJA-2012-069
[16] F. Harzallah-Skhiri and H. BenJannet, "Flavonoids diversification in organs of two prosopis farcta (banks & sol.) eig.(leguminosea, mimosoideae) populations occurring in the northeast and the southeast of Tunisia," J Appl Sci Res, vol. 1, pp. 130-36, 2005.
[17] I. H. Mohammed, E. S. Kakey, and M. M. Farimani, "In Vitro Evaluation of Antioxidant Activates for Parts of Rhubarb (Rheum ribes) and Syrian Mesquite (Prosopis farcta)," 2018.
https://doi.org/10.14500//icpas2018.mim41
[18] B. Gulalp and O. Karcioglu, "The first report of Prosopis farcta ingestion in children: is it serious?," International journal of clinical practice, vol. 62, pp. 829-830, 2008.
https://doi.org/10.1111/j.1742-1241.2006.00941.x
[19] M. R. Saidi, M. H. Farzaei, S. Miraghaee, A. Babaei, B. Mohammadi, M. T. Bahrami, et al., "Antihyperlipidemic effect of Syrian Mesquite (Prosopis farcta) root in high cholesterol diet-fed rabbits," Journal of evidence-based complementary & alternative medicine, vol. 21, pp. NP62-NP66, 2016.
https://doi.org/10.1177/2156587215627552
[20] K. B. Alharbi, H. Mousa, Z. Ibrahim, and I. El-Ashmawy, "Hepatoprotective effect of methanolic extracts of Prosopis farcta and Lycium shawii against carbon tetrachloride-induced hepatotoxicity in rats," J. Biol. Sci, vol. 17, pp. 35-41, 2017.
https://doi.org/10.3923/jbs.2017.35.41
[21] A. Asadollahi, H. Sarir, A. Omidi, and M. B. M. Torbati, "Hepatoprotective potential of prosopis farcta beans extracts against acetaminophen-induced hepatotoxicity in wister rats," International journal of preventive medicine, vol. 5, p. 1281, 2014.
[22] K. Asadollahi, N. Abassi, N. Afshar, M. Alipour, and P. Asadollahi, "Investigation of the effects of Prosopis farcta plant extract on rat's aorta," J Med Plants Res, vol. 4, pp. 142-7, 2010.
[23] S. Salvamani, B. Gunasekaran, N. A. Shaharuddin, S. A. Ahmad, and M. Y. Shukor, "Antiartherosclerotic effects of plant flavonoids," BioMed research international, vol. 2014, 2014.
https://doi.org/10.1155/2014/480258
[24] A. H. Al-Mustafa and O. Y. Al-Thunibat, "Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes," Pak J Biol Sci, vol. 11, pp. 351-358, 2008.
https://doi.org/10.3923/pjbs.2008.351.358
[25] B. Halliwell, "Reactive oxygen species in living systems: source, biochemistry, and role in human disease," The American journal of medicine, vol. 91, pp. S14-S22, 1991.
https://doi.org/10.1016/0002-9343(91)90279-7
[26] M. Vessal, M. Hemmati, and M. Vasei, "Antidiabetic effects of quercetin in streptozocin-induced diabetic rats," Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol. 135, pp. 357-364, 2003.
https://doi.org/10.1016/S1532-0456(03)00140-6
[27] A. Miri, M. Darroudi, R. Entezari, and M. Sarani, "Biosynthesis of gold nanoparticles using Prosopis farcta extract and its in vitro toxicity on colon cancer cells," Research on Chemical Intermediates, vol. 44, pp. 3169-3177, 2018.
https://doi.org/10.1007/s11164-018-3299-y
[28] R. N. Asomugha, N. A. Udowelle, S. J. Offor, C. J. Njoku, I. V. Ofoma, C. C. Chukwuogor, et al., "Heavy metals hazards from Nigerian spices," Roczniki Pa?stwowego Zak?adu Higieny, vol. 67, 2016.
[29] B. Ajiboye, E. Ibukun, G. Edobor, A. Ojo, and S. Onikanni, "Qualitative and quantitative analysis of phytochemicals in Senecio biafrae leaf," International Journal of Inventions in Pharmaceutical Sciences, vol. 1, pp. 428-432, 2013.
[30] M. N. Ghayur, A. H. Gilani, M. B. Afridi, and P. J. Houghton, "Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways," Vascular pharmacology, vol. 43, pp. 234-241, 2005.
https://doi.org/10.1016/j.vph.2005.07.003
[31] D. K. Deka, S. K. Mishra, and V. Raviprakash, "l-arginine-induced dilatation of goat coronary artery involves activation of KATP channels," European journal of pharmacology, vol. 609, p. 113, 2009.
https://doi.org/10.1016/j.ejphar.2009.03.031
[32] D. K. Deka, V. R. Prakash, and S. K. Mishra, "Sodium nitroprusside relaxes goat coronary artery through activation of calcium-dependent K+ channels," 2005.
[33] P. D. Taylor and L. Poston, "The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery," British journal of pharmacology, vol. 113, pp. 801-808, 1994.
https://doi.org/10.1111/j.1476-5381.1994.tb17064.x
[34] M. N. Ghayur and A. H. Gilani, "Ginger lowers blood pressure through blockade of voltage-dependent calcium channels," Journal of cardiovascular pharmacology, vol. 45, pp. 74-80, 2005.
https://doi.org/10.1097/00005344-200501000-00013
[35] J. Bradic, V. Zivkovic, I. Srejovic, V. Jakovljevic, A. Petkovic, T. N. Turnic, et al., "Protective Effects of Galium verum L. Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats," Oxidative Medicine and Cellular Longevity, vol. 2019, 2019.
https://doi.org/10.1155/2019/4235405
[36] P. Marciniak, A. Koli?ska, M. Spochacz, S. Chowa?ski, Z. Adamski, L. Scrano, et al., "Differentiated Effects of Secondary Metabolites from Solanaceae and Brassicaceae Plant Families on the Heartbeat of Tenebrio molitor Pupae," Toxins, vol. 11, p. 287, 2019.
https://doi.org/10.3390/toxins11050287
[37] Y. Wang, Y. Huang, K. S. Lam, Y. Li, W. T. Wong, H. Ye, et al., "Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase," Cardiovascular Research, vol. 82, pp. 484-492, 2009.
https://doi.org/10.1093/cvr/cvp078
[38] J. El Ghoul and M. Ben-Attia, "Vasorelaxant effects of aqueous extract of Zygophyllum Album and antihyperglycemic activities in streptozotocin-induced diabetic mice. J," Diabetes Metab, vol. 5, p. 426, 2014.
https://doi.org/10.4172/2155-6156.1000426
[39] K. M. Ahmed, M. Khan, and B. Shivananda, "Cardiovascular diseases and role of medicinal plants as a re-emerging health aid," Pharmacognosy Reviews, vol. 3, p. 8, 2009.
[40] H.-K. Ng, T.-F. Poh, S.-K. Lam, and S.-Z. Hoe, "Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens," BMC complementary and alternative medicine, vol. 13, p. 188, 2013.
https://doi.org/10.1186/1472-6882-13-188
[41] A. Ahmed and I. Maulood, "The roles of potassium channels in contractile response to urotensin-II in mercury chloride induced endothelial dysfunction in rat aorta," Iranian Journal of Veterinary Research, vol. 19, p. 208, 2018.
[42] I. Grgic, B. P. Kaistha, J. Hoyer, and R. Köhler, "Endothelial Ca2+?activated K+ channels in normal and impaired EDHF-dilator responses-relevance to cardiovascular pathologies and drug discovery," British journal of pharmacology, vol. 157, pp. 509-526, 2009.
https://doi.org/10.1111/j.1476-5381.2009.00132.x
[43] M. Glavind?Kristensen, V. Matchkov, V. B. Hansen, A. Forman, H. Nilsson, and C. Aalkjær, "KATP?channel?induced vasodilation is modulated by the Na, K?pump activity in rabbit coronary small arteries," British journal of pharmacology, vol. 143, pp. 872-880, 2004.
https://doi.org/10.1038/sj.bjp.0706016
[44] F. Lynch, C. Austin, A. Heagerty, and A. Izzard, "Adenosine and hypoxic dilation of rat coronary small arteries: roles of the ATP-sensitive potassium channel, endothelium, and nitric oxide," American Journal of Physiology-Heart and Circulatory Physiology, vol. 290, pp. H1145-H1150, 2006.
https://doi.org/10.1152/ajpheart.00314.2005
[45] C. C. Wu, C. Thiemermann, and J. R. Vane, "Glibenclamide?induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat," British journal of pharmacology, vol. 114, pp. 1273-1281, 1995.
https://doi.org/10.1111/j.1476-5381.1995.tb13343.x
[46] C. Jiang, P. M. Sarrel, D. C. Lindsay, P. A. Poole?Wilson, and P. Collins, "Endothelium?independent relaxation of rabbit coronary artery by 17??oestradiol in vitro," British journal of pharmacology, vol. 104, pp. 1033-1037, 1991.
https://doi.org/10.1111/j.1476-5381.1991.tb12545.x
[47] J. Imig, "Epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid on endothelial and vascular function," in Advances in pharmacology. vol. 77, ed: Elsevier, 2016, pp. 105-141.
https://doi.org/10.1016/bs.apha.2016.04.003
[48] O. G. Khatsenko, S. S. Gross, A. B. Rifkind, and J. R. Vane, "Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants," Proceedings of the National Academy of Sciences, vol. 90, pp. 11147-11151, 1993.
https://doi.org/10.1073/pnas.90.23.11147
[49] S. Takei, T. Iseda, and M. Yokoyama, "Inhibitory effect of clotrimazole on angiogenesis associated with bladder epithelium proliferation in rats," International journal of urology, vol. 10, pp. 78-85, 2003.
https://doi.org/10.1046/j.1442-2042.2003.00575.x
[50] D. K. Deka, V. R. Prakash, and S. Mishra, "Role of nitric oxide in calcium homeostasis in coronary artery of goat," Indian Journal of Pharmacology, vol. 32, pp. 365-368, 2000.
[51] M. Ouedraogo, S. Ouedraogo, L. Ouedraogo, A. Traore, and R. G. Belemtougri, "Pharmacological evaluations for the relaxant effect of the hydroalcoholic extract of Tapinanthus dodoneifolius on rat trachea," African Journal of Traditional, Complementary and Alternative Medicines, vol. 2, pp. 166-176-166-176, 2005.
https://doi.org/10.4314/ajtcam.v2i2.31114
[52] S. Kalsner, "Vasodilator Action of Calcium Antagonists in Coronary ArteriesIn Vitro," Journal of Pharmacology and Experimental Therapeutics, vol. 281, pp. 634-642, 1997.
[53] G. A. Figtree, H. Griffiths, Y.-Q. Lu, C. M. Webb, K. MacLeod, and P. Collins, "Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism," Journal of the American College of Cardiology, vol. 35, pp. 1977-1985, 2000.
https://doi.org/10.1016/S0735-1097(00)00645-8
https://doi.org/10.1155/2014/809741
[2] C. Liu and Y. Huang, "Chinese herbal medicine on cardiovascular diseases and the mechanisms of action," Frontiers in pharmacology, vol. 7, p. 469, 2016.
https://doi.org/10.3389/fphar.2016.00469
[3] H. S. Siddiqi, M. H. Mehmood, N. U. Rehman, and A. H. Gilani, "Studies on the antihypertensive and antidyslipidemic activities of Viola odorata leaves extract," Lipids in health and disease, vol. 11, p. 6, 2012.
https://doi.org/10.1186/1476-511X-11-6
[4] H. A. Twaij and E. A. Al-Dujaili, "Evaluation of the anti-diabetic and anti-ulcer properties of some Jordanian and Iraqi medicinal plants; a screening study," JMED Research, vol. 2014, 2014.
https://doi.org/10.5171/2014.539605
[5] E. Karimi, A. Aidy, and N. Abbasi, "Quantitative HPLC Analysis of Phenolic Compounds in Prosopis Farcta from two Different Ecological Zones of Iran," Chem Technol Ind J, vol. 12, p. 116, 2017.
[6] A. M. Saad, M. A. Ghareeb, M. S. Abdel-Aziz, H. M. F. Madkour, O. M. Khalaf, A. K. El-Ziaty, et al., "Chemical constituents and biological activities of different solvent extracts of Prosopis farcta growing in Egypt," Journal of Pharmacognosy and Phytotherapy, vol. 9, pp. 67-76, 2017.
https://doi.org/10.5897/JPP2017.0452
[7] A. Al-jeboory and K. F. Dizaye, "Cardiovascular effects of vitexin isolated from Prosopis farcta," Iraqi Journal of Pharmacy, vol. 6, pp. 14-19, 2006.
https://doi.org/10.33899/iphr.2006.50547
[8] M. S. Ali-Shtayeh, R. M. Jamous, J. H. Al-Shafie, W. A. Elgharabah, F. A. Kherfan, K. H. Qarariah, et al., "Traditional knowledge of wild edible plants used in Palestine (Northern West Bank): a comparative study," Journal of Ethnobiology and Ethnomedicine, vol. 4, p. 13, 2008.
https://doi.org/10.1186/1746-4269-4-13
[9] M. Mollashahi, M. Tehranipour, J. Khayyatzade, and B. ZahraJavad Moosavi, "The neuroprotective effects of Prosopis farcta pod aqueous and ethanol extracts on spinal cord ?-motoneurons neuronal density after sciatic nerve injury in rats," Life Sci. J, vol. 10, pp. 293-297, 2013.
[10] A. Moayeri, M. Azimi, E. Karimi, A. Aidy, and N. Abbasi, "Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats," Medical science monitor basic research, vol. 24, p. 151, 2018.
https://doi.org/10.12659/MSMBR.909930
[11] S. Al-Quran, "Taxonomical and pharmacological survey of therapeutic plants in Jordan," J Nat Prod, vol. 1, pp. 10-26, 2008.
[12] A. Ranjbar-Heidari, J. Khaiatzadeh, N. Mahdavi-Shahri, and M. Tehranipoor, "The effect of fruit pod powder and aquatic extract of Prosopis farcta on healing cutaneous wounds in diabetic rat," ???? ??????? ???? ????? ??????, vol. 14, pp. 16-20, 2012.
[13] M. Dashtban, H. Sarir, and A. Omidi, "The effect of Prosopis farcta beans extract on blood biochemical parameters in streptozotocin-induced diabetic male rats," Advanced biomedical research, vol. 5, 2016.
https://doi.org/10.4103/2277-9175.185575
[14] A. L. Lamarque, D. M. Maestri, N. R. Grosso, J. A. Zygadlo, and C. A. Guzmán, "Proximate composition and seed lipid components of some Prosopis (Leguminosae) from Argentina," Journal of the Science of Food and Agriculture, vol. 66, pp. 323-326, 1994.
https://doi.org/10.1002/jsfa.2740660309
[15] B. Huisamen, C. George, S. Genade, and D. Dietrich, "Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes," Cardiovascular journal of Africa, vol. 24, p. 10, 2013.
https://doi.org/10.5830/CVJA-2012-069
[16] F. Harzallah-Skhiri and H. BenJannet, "Flavonoids diversification in organs of two prosopis farcta (banks & sol.) eig.(leguminosea, mimosoideae) populations occurring in the northeast and the southeast of Tunisia," J Appl Sci Res, vol. 1, pp. 130-36, 2005.
[17] I. H. Mohammed, E. S. Kakey, and M. M. Farimani, "In Vitro Evaluation of Antioxidant Activates for Parts of Rhubarb (Rheum ribes) and Syrian Mesquite (Prosopis farcta)," 2018.
https://doi.org/10.14500//icpas2018.mim41
[18] B. Gulalp and O. Karcioglu, "The first report of Prosopis farcta ingestion in children: is it serious?," International journal of clinical practice, vol. 62, pp. 829-830, 2008.
https://doi.org/10.1111/j.1742-1241.2006.00941.x
[19] M. R. Saidi, M. H. Farzaei, S. Miraghaee, A. Babaei, B. Mohammadi, M. T. Bahrami, et al., "Antihyperlipidemic effect of Syrian Mesquite (Prosopis farcta) root in high cholesterol diet-fed rabbits," Journal of evidence-based complementary & alternative medicine, vol. 21, pp. NP62-NP66, 2016.
https://doi.org/10.1177/2156587215627552
[20] K. B. Alharbi, H. Mousa, Z. Ibrahim, and I. El-Ashmawy, "Hepatoprotective effect of methanolic extracts of Prosopis farcta and Lycium shawii against carbon tetrachloride-induced hepatotoxicity in rats," J. Biol. Sci, vol. 17, pp. 35-41, 2017.
https://doi.org/10.3923/jbs.2017.35.41
[21] A. Asadollahi, H. Sarir, A. Omidi, and M. B. M. Torbati, "Hepatoprotective potential of prosopis farcta beans extracts against acetaminophen-induced hepatotoxicity in wister rats," International journal of preventive medicine, vol. 5, p. 1281, 2014.
[22] K. Asadollahi, N. Abassi, N. Afshar, M. Alipour, and P. Asadollahi, "Investigation of the effects of Prosopis farcta plant extract on rat's aorta," J Med Plants Res, vol. 4, pp. 142-7, 2010.
[23] S. Salvamani, B. Gunasekaran, N. A. Shaharuddin, S. A. Ahmad, and M. Y. Shukor, "Antiartherosclerotic effects of plant flavonoids," BioMed research international, vol. 2014, 2014.
https://doi.org/10.1155/2014/480258
[24] A. H. Al-Mustafa and O. Y. Al-Thunibat, "Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes," Pak J Biol Sci, vol. 11, pp. 351-358, 2008.
https://doi.org/10.3923/pjbs.2008.351.358
[25] B. Halliwell, "Reactive oxygen species in living systems: source, biochemistry, and role in human disease," The American journal of medicine, vol. 91, pp. S14-S22, 1991.
https://doi.org/10.1016/0002-9343(91)90279-7
[26] M. Vessal, M. Hemmati, and M. Vasei, "Antidiabetic effects of quercetin in streptozocin-induced diabetic rats," Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol. 135, pp. 357-364, 2003.
https://doi.org/10.1016/S1532-0456(03)00140-6
[27] A. Miri, M. Darroudi, R. Entezari, and M. Sarani, "Biosynthesis of gold nanoparticles using Prosopis farcta extract and its in vitro toxicity on colon cancer cells," Research on Chemical Intermediates, vol. 44, pp. 3169-3177, 2018.
https://doi.org/10.1007/s11164-018-3299-y
[28] R. N. Asomugha, N. A. Udowelle, S. J. Offor, C. J. Njoku, I. V. Ofoma, C. C. Chukwuogor, et al., "Heavy metals hazards from Nigerian spices," Roczniki Pa?stwowego Zak?adu Higieny, vol. 67, 2016.
[29] B. Ajiboye, E. Ibukun, G. Edobor, A. Ojo, and S. Onikanni, "Qualitative and quantitative analysis of phytochemicals in Senecio biafrae leaf," International Journal of Inventions in Pharmaceutical Sciences, vol. 1, pp. 428-432, 2013.
[30] M. N. Ghayur, A. H. Gilani, M. B. Afridi, and P. J. Houghton, "Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways," Vascular pharmacology, vol. 43, pp. 234-241, 2005.
https://doi.org/10.1016/j.vph.2005.07.003
[31] D. K. Deka, S. K. Mishra, and V. Raviprakash, "l-arginine-induced dilatation of goat coronary artery involves activation of KATP channels," European journal of pharmacology, vol. 609, p. 113, 2009.
https://doi.org/10.1016/j.ejphar.2009.03.031
[32] D. K. Deka, V. R. Prakash, and S. K. Mishra, "Sodium nitroprusside relaxes goat coronary artery through activation of calcium-dependent K+ channels," 2005.
[33] P. D. Taylor and L. Poston, "The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery," British journal of pharmacology, vol. 113, pp. 801-808, 1994.
https://doi.org/10.1111/j.1476-5381.1994.tb17064.x
[34] M. N. Ghayur and A. H. Gilani, "Ginger lowers blood pressure through blockade of voltage-dependent calcium channels," Journal of cardiovascular pharmacology, vol. 45, pp. 74-80, 2005.
https://doi.org/10.1097/00005344-200501000-00013
[35] J. Bradic, V. Zivkovic, I. Srejovic, V. Jakovljevic, A. Petkovic, T. N. Turnic, et al., "Protective Effects of Galium verum L. Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats," Oxidative Medicine and Cellular Longevity, vol. 2019, 2019.
https://doi.org/10.1155/2019/4235405
[36] P. Marciniak, A. Koli?ska, M. Spochacz, S. Chowa?ski, Z. Adamski, L. Scrano, et al., "Differentiated Effects of Secondary Metabolites from Solanaceae and Brassicaceae Plant Families on the Heartbeat of Tenebrio molitor Pupae," Toxins, vol. 11, p. 287, 2019.
https://doi.org/10.3390/toxins11050287
[37] Y. Wang, Y. Huang, K. S. Lam, Y. Li, W. T. Wong, H. Ye, et al., "Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase," Cardiovascular Research, vol. 82, pp. 484-492, 2009.
https://doi.org/10.1093/cvr/cvp078
[38] J. El Ghoul and M. Ben-Attia, "Vasorelaxant effects of aqueous extract of Zygophyllum Album and antihyperglycemic activities in streptozotocin-induced diabetic mice. J," Diabetes Metab, vol. 5, p. 426, 2014.
https://doi.org/10.4172/2155-6156.1000426
[39] K. M. Ahmed, M. Khan, and B. Shivananda, "Cardiovascular diseases and role of medicinal plants as a re-emerging health aid," Pharmacognosy Reviews, vol. 3, p. 8, 2009.
[40] H.-K. Ng, T.-F. Poh, S.-K. Lam, and S.-Z. Hoe, "Potassium channel openers and prostacyclin play a crucial role in mediating the vasorelaxant activity of Gynura procumbens," BMC complementary and alternative medicine, vol. 13, p. 188, 2013.
https://doi.org/10.1186/1472-6882-13-188
[41] A. Ahmed and I. Maulood, "The roles of potassium channels in contractile response to urotensin-II in mercury chloride induced endothelial dysfunction in rat aorta," Iranian Journal of Veterinary Research, vol. 19, p. 208, 2018.
[42] I. Grgic, B. P. Kaistha, J. Hoyer, and R. Köhler, "Endothelial Ca2+?activated K+ channels in normal and impaired EDHF-dilator responses-relevance to cardiovascular pathologies and drug discovery," British journal of pharmacology, vol. 157, pp. 509-526, 2009.
https://doi.org/10.1111/j.1476-5381.2009.00132.x
[43] M. Glavind?Kristensen, V. Matchkov, V. B. Hansen, A. Forman, H. Nilsson, and C. Aalkjær, "KATP?channel?induced vasodilation is modulated by the Na, K?pump activity in rabbit coronary small arteries," British journal of pharmacology, vol. 143, pp. 872-880, 2004.
https://doi.org/10.1038/sj.bjp.0706016
[44] F. Lynch, C. Austin, A. Heagerty, and A. Izzard, "Adenosine and hypoxic dilation of rat coronary small arteries: roles of the ATP-sensitive potassium channel, endothelium, and nitric oxide," American Journal of Physiology-Heart and Circulatory Physiology, vol. 290, pp. H1145-H1150, 2006.
https://doi.org/10.1152/ajpheart.00314.2005
[45] C. C. Wu, C. Thiemermann, and J. R. Vane, "Glibenclamide?induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat," British journal of pharmacology, vol. 114, pp. 1273-1281, 1995.
https://doi.org/10.1111/j.1476-5381.1995.tb13343.x
[46] C. Jiang, P. M. Sarrel, D. C. Lindsay, P. A. Poole?Wilson, and P. Collins, "Endothelium?independent relaxation of rabbit coronary artery by 17??oestradiol in vitro," British journal of pharmacology, vol. 104, pp. 1033-1037, 1991.
https://doi.org/10.1111/j.1476-5381.1991.tb12545.x
[47] J. Imig, "Epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid on endothelial and vascular function," in Advances in pharmacology. vol. 77, ed: Elsevier, 2016, pp. 105-141.
https://doi.org/10.1016/bs.apha.2016.04.003
[48] O. G. Khatsenko, S. S. Gross, A. B. Rifkind, and J. R. Vane, "Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants," Proceedings of the National Academy of Sciences, vol. 90, pp. 11147-11151, 1993.
https://doi.org/10.1073/pnas.90.23.11147
[49] S. Takei, T. Iseda, and M. Yokoyama, "Inhibitory effect of clotrimazole on angiogenesis associated with bladder epithelium proliferation in rats," International journal of urology, vol. 10, pp. 78-85, 2003.
https://doi.org/10.1046/j.1442-2042.2003.00575.x
[50] D. K. Deka, V. R. Prakash, and S. Mishra, "Role of nitric oxide in calcium homeostasis in coronary artery of goat," Indian Journal of Pharmacology, vol. 32, pp. 365-368, 2000.
[51] M. Ouedraogo, S. Ouedraogo, L. Ouedraogo, A. Traore, and R. G. Belemtougri, "Pharmacological evaluations for the relaxant effect of the hydroalcoholic extract of Tapinanthus dodoneifolius on rat trachea," African Journal of Traditional, Complementary and Alternative Medicines, vol. 2, pp. 166-176-166-176, 2005.
https://doi.org/10.4314/ajtcam.v2i2.31114
[52] S. Kalsner, "Vasodilator Action of Calcium Antagonists in Coronary ArteriesIn Vitro," Journal of Pharmacology and Experimental Therapeutics, vol. 281, pp. 634-642, 1997.
[53] G. A. Figtree, H. Griffiths, Y.-Q. Lu, C. M. Webb, K. MacLeod, and P. Collins, "Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism," Journal of the American College of Cardiology, vol. 35, pp. 1977-1985, 2000.
https://doi.org/10.1016/S0735-1097(00)00645-8
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How to Cite
[1]
R. A. Rasheed and I. Salih Ibrahim Kakey, “Effects of Prosopis farcta Root Extract in the Vascular Reactivity of Isolated Goat Coronary Artery”, KJAR, pp. 1–19, Aug. 2019, doi: 10.24017/science.2019.ICHMS.1.
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21-08-2019
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Pure and Applied Science
