The Correlation Between Lipid Profile and Renal Function Tests in Patients with Cardiovascular Disease in Erbil city, Kurdistan Region of Iraq
https://doi.org/10.24017/science.2020.2.5
Abstract views: 1036 / PDF downloads: 647Abstract
Cardiovascular disease patients frequently suffer from the incidence of renal dysfunctions, the prevalence of the correlation, however, remains ambiguous. This study aims to see how CVD and renal function are related to the subjected group of patients suffer from symptoms of CVD. The method recruited for this objective was using of serum lipid profile test as a marker for evaluating the CVD and making correlations to the blood urea, serum uric acid, and serum creatinine levels as markers for assessing renal function on 159 individuals with CVD symptoms in Erbil city. Two statistical analysis methods (The linear regression and Pearson’s correlation) were employed for determining the existence from a lack of relationship between them. The results showed a statistically significant correlation p<0.05 by both methods between the renal function markers and TC. The UA was correlated to TG, LDL-C, and VLDL-C p<0.05 by regression analysis. The SCr was correlated to TG and LDL-C p<0.05 by both methods, and to VLDL by regression analysis. According to the outcome of the current study both lipid profile and renal function markers are correlated in mostly a statistically significant manner. Yet, the results are not conclusive, further studies are needed in this area for indemnify the irrefutable evidence concerning this relation.
Keywords:
Lipid profile, Renal function, CVD, Kidney disease
References
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https://doi.org/10.2116/analsci.24.1589
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https://doi.org/10.3325/cmj.2010.51.1
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https://doi.org/10.1681/ASN.V122218
[21] M. J. Brown et al., "Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT).," Lancet (London, England), vol. 356, no. 9227, pp. 366-372, Jul. 2000, doi: 10.1016/S0140-6736(00)02527-7.
https://doi.org/10.1016/S0140-6736(00)02527-7
[22] J. F. Mann, H. C. Gerstein, J. Pogue, J. Bosch, and S. Yusuf, "Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial.," Ann. Intern. Med., vol. 134, no. 8, pp. 629-636, Apr. 2001, doi: 10.7326/0003-4819-134-8-200104170-00007.
https://doi.org/10.7326/0003-4819-134-8-200104170-00007
[23] L. M. Ruilope, D. J. Van Veldhuisen, E. Ritz, and T. F. Luscher, "Renal function: The cinderella of cardiovascular risk profile," Journal of the American College of Cardiology, vol. 38, no. 7. pp. 1782-1787, 2001, doi: 10.1016/S0735-1097(01)01627-8.
https://doi.org/10.1016/S0735-1097(01)01627-8
[24] L. Zhang et al., "Prevalence of chronic kidney disease in China: a cross-sectional survey.," Lancet (London, England), vol. 379, no. 9818, pp. 815-822, Mar. 2012, doi: 10.1016/S0140-6736(12)60033-6.
https://doi.org/10.1016/S0140-6736(12)60033-6
[25] J. Coresh et al., "Prevalence of chronic kidney disease in the United States.," JAMA, vol. 298, no. 17, pp. 2038-2047, Nov. 2007, doi: 10.1001/jama.298.17.2038.
https://doi.org/10.1001/jama.298.17.2038
[26] S. I. Hallan et al., "International comparison of the relationship of chronic kidney disease prevalence and ESRD risk.," J. Am. Soc. Nephrol., vol. 17, no. 8, pp. 2275-2284, Aug. 2006, doi: 10.1681/ASN.2005121273.
https://doi.org/10.1681/ASN.2005121273
[27] A. A. House et al., "Heart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference," Kidney Int., vol. 95, no. 6, pp. 1304-1317, Jun. 2019, doi: 10.1016/j.kint.2019.02.022.
https://doi.org/10.1016/j.kint.2019.02.022
[28] P. O. Attman and O. Samuelsson, "Dyslipidemia of kidney disease.," Curr. Opin. Lipidol., vol. 20, no. 4, pp. 293-299, Aug. 2009, doi: 10.1097/MOL.0b013e32832dd832.
https://doi.org/10.1097/MOL.0b013e32832dd832
[29] N. D. Vaziri, "Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences.," Am. J. Physiol. Renal Physiol., vol. 290, no. 2, pp. F262-72, Feb. 2006, doi: 10.1152/ajprenal.00099.2005.
https://doi.org/10.1152/ajprenal.00099.2005
[30] P. O. Attman, O. Samuelsson, and P. Alaupovic, "Lipoprotein metabolism and renal failure.," Am. J. kidney Dis. Off. J. Natl. Kidney Found., vol. 21, no. 6, pp. 573-592, Jun. 1993, doi: 10.1016/s0272-6386(12)80030-8.
https://doi.org/10.1016/S0272-6386(12)80030-8
[31] L. A. Stevens and A. S. Levey, "Measured GFR as a confirmatory test for estimated GFR.," J. Am. Soc. Nephrol., vol. 20, no. 11, pp. 2305-2313, Nov. 2009, doi: 10.1681/ASN.2009020171.
https://doi.org/10.1681/ASN.2009020171
[32] M. T. Jalali, A. M. Honomaror, A. Rekabi, and M. Latifi, "Reference ranges for serum total cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol and triglycerides in healthy iranian ahvaz population," Indian J. Clin. Biochem., vol. 28, no. 3, pp. 277-282, 2013, doi: 10.1007/s12291-012-0268-x.
https://doi.org/10.1007/s12291-012-0268-x
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How to Cite
[1]
H. R. Baqi and S. R. K. Rostam, “The Correlation Between Lipid Profile and Renal Function Tests in Patients with Cardiovascular Disease in Erbil city, Kurdistan Region of Iraq”, KJAR, vol. 5, no. 2, pp. 51–59, Nov. 2020, doi: 10.24017/science.2020.2.5.
Published
19-11-2020
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Section
Pure and Applied Science
